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Title: The mechanistic roles of Iroquois genes in embryonic heart development and physiology in zebrafish
Other Titles: Ji yin Iroquois zai ban ma yu de pei tai xin zang fa yu he sheng li shang suo dan dang de gong neng
基因 Iroquois 在斑馬魚的胚胎心臟發育和生理上所擔當的功能
Authors: Lee, Sin Ting ( 李倩婷)
Department: Department of Biology and Chemistry
Degree: Master of Philosophy
Issue Date: 2011
Publisher: City University of Hong Kong
Subjects: Zebra danio -- Genetics.
Zebra danio -- Embryos -- Physiology.
Notes: CityU Call Number: QL638.C94 L44 2011
ix, 129 leaves : ill. (some col.) 30 cm.
Thesis (M.Phil.)--City University of Hong Kong, 2011.
Includes bibliographical references (leaves 109-129)
Type: thesis
Abstract: irx1a expression is found in the developing ventricle of the zebrafish embryos. irx1a morphants displayed phenotypes including dilated ventricle, pericardial effusion, pericardial edema and heart-looping defects. Electrocardiograms (ECGs) of the irx1a morphants showed a slower heart rate and a prolonged QT-interval resembling the phenotype of certain human congenital heart diseases. Arrhythmias were occasionally observed in the morphants. There is a down-regulation of irx2a, tbx5.1 and scn5Laa in the developing heart of the irx1a morphants. irx2a morphants and irx1a-and-irx2a-double-knockdown morphants displayed similar phenotypes and gene expression as shown in irx1a morphants. It suggested that the two iroquois genes may share similar roles in regulating cardiogenesis and cardiac functioning while irx2a is a potential downstream target of irx1a. Study using the zebrafish breakdance mutant proposed there is a regulatory relationship between kcnh2, irx1a and irx2a in a heart-specific pathway.
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