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|Title: ||The mechanistic roles of Iroquois genes in embryonic heart development and physiology in zebrafish|
|Other Titles: ||Ji yin Iroquois zai ban ma yu de pei tai xin zang fa yu he sheng li shang suo dan dang de gong neng|
基因 Iroquois 在斑馬魚的胚胎心臟發育和生理上所擔當的功能
|Authors: ||Lee, Sin Ting ( 李倩婷)|
|Department: ||Department of Biology and Chemistry|
|Degree: ||Master of Philosophy|
|Issue Date: ||2011|
|Publisher: ||City University of Hong Kong|
|Subjects: ||Zebra danio -- Genetics.|
Zebra danio -- Embryos -- Physiology.
|Notes: ||CityU Call Number: QL638.C94 L44 2011|
ix, 129 leaves : ill. (some col.) 30 cm.
Thesis (M.Phil.)--City University of Hong Kong, 2011.
Includes bibliographical references (leaves 109-129)
|Abstract: ||irx1a expression is found in the developing ventricle of the zebrafish embryos.
irx1a morphants displayed phenotypes including dilated ventricle, pericardial
effusion, pericardial edema and heart-looping defects. Electrocardiograms (ECGs)
of the irx1a morphants showed a slower heart rate and a prolonged QT-interval
resembling the phenotype of certain human congenital heart diseases. Arrhythmias
were occasionally observed in the morphants. There is a down-regulation of irx2a,
tbx5.1 and scn5Laa in the developing heart of the irx1a morphants. irx2a
morphants and irx1a-and-irx2a-double-knockdown morphants displayed similar
phenotypes and gene expression as shown in irx1a morphants. It suggested that
the two iroquois genes may share similar roles in regulating cardiogenesis and
cardiac functioning while irx2a is a potential downstream target of irx1a. Study
using the zebrafish breakdance mutant proposed there is a regulatory relationship
between kcnh2, irx1a and irx2a in a heart-specific pathway.|
|Online Catalog Link: ||http://lib.cityu.edu.hk/record=b4086431|
|Appears in Collections:||BCH - Master of Philosophy |
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