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|Title: ||Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos|
|Other Titles: ||4-jia ji bian ya ji zhang nao dui ban ma yu pei tai shen jing he ji ru fa yu de ying xiang|
|Authors: ||Li, Wai Tsun Vincent ( 李煒俊)|
|Department: ||Department of Biology and Chemistry|
|Degree: ||Master of Philosophy|
|Issue Date: ||2011|
|Publisher: ||City University of Hong Kong|
|Subjects: ||Zebra danio -- Effect of chemicals on.|
Camphor -- Physiological effect.
|Notes: ||CityU Call Number: QL638.C94 L5 2011|
ix, 119 leaves : ill. (some col.) 30 cm.
Thesis (M.Phil.)--City University of Hong Kong, 2011.
Includes bibliographical references (leaves 97-118)
|Abstract: ||The effects of UV light on human is of increasing public concern. The majority of
negative effects caused by over-exposure of sunlight include sunburn and
light-induced cell injury. UV filter is used extensively in many sunscreen products
to protect human skin from the negative effects of UV radiation. Methylbenzylidene
camphor (4-MBC) is one of the active ingredients in sunscreens products. 4-MBC is
a UV filter that dissipates the absorbed radiation energy as heat by photo-induced
geometrical isomerization. Its adverse effects has been studied and it was found that
4-MBC has potential to act as endocrine disruptor. It has been shown to exert
estrogenic effects in both in vitro and in vivo studies. However, little information is
known about the neurotoxicity in early vertebrate development. In this study, the
effects of 4-MBC exposure on zebrafish embryonic development were examined.
Embryos exposed to 4-MBC at nominal concentration of 15uM displayed abnormal
axial curvature and exhibited ineffective tail flip and muscle contractions along the
body axis in response to tactile stimulation. 4-MBC exposed embryos showed
abnormal notochord pattern and loss of muscle pioneer cells, which may lead to the
disruption of motor axon innervations and slow muscle development during
somitogenesis. Taking these results together, it can be proposed that 4-MBC causes
locomotion defects by impairing muscular and neuronal development.|
|Online Catalog Link: ||http://lib.cityu.edu.hk/record=b4086453|
|Appears in Collections:||BCH - Master of Philosophy |
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