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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2031/5380
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| Title: | A Mechanical Model of Biological Cells in Microinjection |
| Authors: | Tan, Youhua (譚又華)
Dr. Sun, Dong
Prof. Huang, Wenhao |
| Department: | Department of Manufacturing Engineering and Engineering Management, Suzhou Research Institute (Tan, Y.H.); Department of Manufacturing Engineering and Engineering Management (Dr. Sun, D.) |
| Issue Date: | Feb-2009 |
| Description: | Won the T.J. Tarn Best Paper Award in the 2008 IEEE International Conference on Robotics and Biomimetics organized by the 2008 IEEE International Conference on Robotics and Biomimetics Organizing Committee. |
| Type: | Research Paper |
| Abstract: | Microinjection is an effective technique to introduce
foreign materials into a biological cell. Although great
developments have been achieved, a full understanding of the
mechanical response of biological cells to injection operation
remains deficient. In this paper, a mechanical model based on
membrane theory is proposed. This model utilizes the
Mooney-Rivlin material to model the deformation of
biomembrane. The relationship between the injection force and
the deformation of biological cells is established through the
quasi-static equilibrium equations, which are solved by the
Runge-Kutta numerical method. To verify the mechanical model,
experiments are performed on microinjection of zebrafish and
medaka embryos. It is demonstrated that the modeling results
agree well with the experimental data, which shows that the proposed model can be used to estimate the mechanical properties
of cell biomembranes. |
| URI: | http://hdl.handle.net/2031/5380 |
| Appears in Collections: | Student Works With External Awards
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